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Members (84)

From across Europe and beyond, and from a variety of backgrounds, our members share many common goals. Our members’ diversity, expertise and openness to collaborate is our strength. Search our members list here. Filter using our search options. All members are encouraged to network and develop as a community that fosters collaboration. Find your match, share, engage and complement expertise.

Showing 1-10 of 84 members.

Sabina Kleitman

Higher education
Home country
Australia
Type of research activities
Applied research
Fields of research
Psychology and cognitive sciences
Specialisation and expertise
Her principal research lies in decision-making (confidence & its calibration, meta-reasoning, metacognition), individual differences (cognitive abilities, resilience/adaptability, personality), and cognitive psychology. In her research during the COVID-19 pandemic, she was interested in diverse psychological and external factors that impacted people’s ability to adapt effectively to changes, their decisions, and their mental fitness.
Language(s)
English

Kastenhofer Karen

Higher education
Home country
Austria
Type of research activities
Applied research, Basic research, Experimental development
Fields of research
Education, Sociology, Political science, Other social sciences
Specialisation and expertise

As a Science & Technology Studies scholar and Technology Assessment practitioner, I mostly do qualitative research, including ethnography, qualitative interviews and discourse analysis. I refer to concepts such as epistemic cultures, scientific communities, technoscience, innovation regimes, risk cultures or risk governance. With my online-survey on Covid-19, I was interested in expert opinions from diverse disciplines and countries on side-effects, opportunities and potentials for preparedness pertaining to the current and future pandemics.

Language(s)
German, English

Matvey Sprindzuk

Business enterprise
Home country
Belarus
Type of research activities
Applied research, Basic research, Experimental development
Fields of research
Natural sciences, Engineering and technology, Medical and health sciences
Specialisation and expertise
Bioinformatics, genomics, medicine, virology, microbiology, image processing, AI, software engineering, COVID-19, tuberculosis, mathematical modelling, applied mathematics, medical systems, data processing automation
Language(s)
English

Covidpedia Labs

Business enterprise
Home country
Belgium
Type of research activities
Applied research, Basic research, Experimental development
Fields of research
Education, Sociology, Political science, Media and communications, Medical and health sciences, Humanities and the arts
Specialisation and expertise
Covidpedia Labs is an extensive platform on the COVID-19 pandemic - the platform distils and detangles information that is misleading or intentionally disinforming people; releases up to date information on the pandemic; and scientific reporting.
Language(s)
English, English, French

Instituto Oswaldo Cruz_Fiocruz

Government & public sector
Home country
Brazil
Type of research activities
Applied research, Basic research, Experimental development
Fields of research
Education, Sociology, Other social sciences, Natural sciences, Medical and health sciences
Specialisation and expertise

The high technological complexity of products and services is a feature of the health sector. Therefore, the relationship between the scientific base of universities and institutes and the pharmaceutical industry is a necessary condition for national technological advances in this segment. One strategy already adopted and consolidated by the countries that are at the cutting edge of technological development and that, from the advent of the Innovation Law - Law 10.973/2004 - has been increasingly embraced by Brazilian institutions and Fiocruz is one of the most prominent health institutions from Brazil immersed in the research innovation challenges.

Fiocruz produces, disseminates, and share knowledge and technologies and contributes to the promotion of health and quality of life of the population.  Besides the reduction of social inequalities and the national dynamics of innovation, with the defense of the right to health and full citizenship as central values, it uses science and innovation as the basis of socio-economic development and health promotion.

 COVID 19, HIV-1, HIV-1 / 2, Chagas’ disease, dengue fever, leishmaniasis, leptospirosis, arboviruses, influenza, and many other diseases are under research at Instituto Oswaldo Cruz. Please take a look at the technological showcase in COVID 19, shared in the links to the research work window.

 

Language(s)
English, Portuguese

Fundação Getulio Vargas

Higher education
Home country
Brazil
Type of research activities
Applied research, Basic research, Experimental development
Fields of research
Economics and Business, Education, Sociology, Law, Political science, Social and economic geography, Media and communications, Other social sciences, Engineering and technology, Medical and health sciences, Humanities and the arts
Specialisation and expertise

Regarding the pandemics impacts and response, we believe that the Brazilian case, given its diversity, persistent inequality and continental dimensions, can bring insights and lessons that will be useful to both poor and rich countries. In short, FGV Social will process multiple sources of information in order to assess all policies and actions implemented in Brazil to diminish the pandemics’ negative impacts, especially on vulnerable groups such as the elderly, individuals with morbidities, through social distancing etc, besides proposing solutions to improve or change them. Some of the expected outcomes of the research partnership are the following: i) Empirical data diagnosis describing the reality of the vulnerable population before and after the pandemics in Brazil and elsewhere using fresh sources of microdata (e.g. first-hand assessment on poverty and inequality changes and the identification of new behavioural and perceptions patterns). ii) Estimating the coverage and effectiveness of the government measures taken to mitigate the pandemics’ effects, in addition to propose upgrades, complementary policies and empirical experiments. iii) Impact the public opinion through the diffusion of our previous research results in a wide and friendly data set with interactive maps, rankings, tables and simulators based on statistical models are available in the internet at: https://cps.fgv.br/en/covid-impacts For more information and for contacting FGV Social, feel free to e-mail Marcelo Neri, the Centre’s Director, at marcelo.neri@fgv.br. The Centre for Bureaucracy Studies (NEB) is a research group at FGV that analyses public policies by considering the public servants that conceive them in practice. During the coronavirus pandemics, NEB has conducted research to understand the effects of the pandemics on frontline workers from the areas of health, social assistance and security, drawing from surveys and interviews and collecting data with more than 10000 frontline workers throughout Brazil to assess how the pandemics has altered work practices and how frontline workers have experienced these changes. Besides that, NEB has also analysed the effects of the pandemics on gender, with a focus on female health workers. For more information and for contacting NEB, feel free to e-mail Gabriela Lotta, Professor at Public Administration at FGV and NEB’s Coordinator, at the address gabriela.lotta@fgv.br.

Language(s)
Portuguese, English, Spanish

Micar Innovation (Micar21)

Business enterprise
Home country
Bulgaria
Type of research activities
Applied research, Experimental development
Fields of research
Natural sciences, Medical and health sciences, Agricultural and veterinary sciences
Specialisation and expertise

The aim of Micar21 is to provide urgently high quality data about the effect of the Next Covid-19 mutations.

We want to provide example of science validation of the capability and speed of Micar21 Drug Discovery Platform, which can be viewed and validated through science publications. Early of December no one had accurate data on the effect of the new Covid19 - UK & South Africa mutations on the action of vaccines and on the binding of the virus to ACE2, so Micar21 decided to calculate pro-bono and support science worldwide. On 16.12.2020 - Micar21 starts insilico calculations. On 26.12.2020 - first version of our science publication - with calculation for English mutation COVID19. On 31.12.2020 - second version of our science publication - with calculation for South African mutation COVID19 is included and we published our scientific publication: https://www.biorxiv.org/content/10.1101/2020.12.23.424283v2.article-metrics Dr. Filip Fratev (Micar21) is the sole author of the science publication. In less than 5 months there are already 22 citations (very good result). Our competitors appeared with insilico data for Covid19 Mutations at the end of January 2021 (can be traced through science publications) On 14.02.2021 (sent on 14.02.2021 - published on 23.02.2021) science publication by Oxford, validates Micar21 insilico results with experimental data: https://www.cell.com/cell/pdf/S0092-8674(21)00226-9.pdf Here, through the experimental data, our Micar21 insilico data calculated in December 2020 are proved. Micar21 predicted in silico the stronger N501Y mutant binding to ACE2 (-1.42 kcal/mol) whereas months later experimental data shown a value of (-1.40 kcal/mol), thus, confirming that our in silico results was precise. The aim of Micar21 study and new paper was to provide urgently high quality data about the effect of the UK and South African mutations. However, during the process of revision of the paper many experimental studies became available which was an excellent opportunity for a validation of the in silico approaches employed here and in particular protein-protein FEP. Also, we can compare our results to other data obtained by theoretical approaches which can be viewed and validated through other science publications and showed in our new science publication in Journal of Chemical Information and Modelling - under final review: http://micar21.com/Covid19_UK_SA_mutation.pdf

22 NOV 2021 Micar21 publish at Journal of Chemical Information and Modeling

N501Y and K417N Mutations in the Spike Protein of SARS-CoV-2 Alter the Interactions with Both hACE2 and Human-Derived Antibody: A Free Energy of Perturbation Retrospective Study

https://pubs.acs.org/doi/10.1021/acs.jcim.1c01242 

 

27 Nov 2021 / 3:08 CET  Filip Fratev / Micar Innovation (Micar21)

We plan to calculate the binding to ACE2 of all individual B.1.1.529 mutations and their total effect.

The new B.1.1.529 SARS-CoV-2 lineage (Omicron) looks really terrible with totally 7 mutations located at the RBD-ACE2 binding surface. To urgently provide a high quality data we are performing with Suman Sirimulla (UTEP) a Free energy of Perturbation (FEP) assessments of the impact of all mutations. The FEP method has been shown in our previous studies to be highly accurate for Alpha (1) and Mu (2) variants. We have already calculated that the G496S mutation lead to an additional increase in the RBD-ACE2 binding by 4 times in comparison to the presence of only N501Y mutation (Alpha variant). The latter mutation is included in our set up, thus we can conclude that G496S plus N501Y mutations result in a totally of 11 times increase of the RBD-ACE2 binding.

We plan to calculate the binding to ACE2 of all individual B.1.1.529 mutations and their total effect. Also, we will assay how these mutations will impact various antibody classes. We will keep you updated!

(1) N501Y and K417N Mutations in the Spike Protein of SARS-CoV-2 Alter the Interactions with Both hACE2 and Human-Derived Antibody: A Free Energy of Perturbation Retrospective Study - https://pubs.acs.org/doi/10.1021/acs.jcim.1c01242 The N501Y and K417N mutations in the spike protein of SARS-CoV-2 alter the interactions with both hACE2 and human derived antibody: A Free energy of perturbation study - https://www.biorxiv.org/content/10.1101/2020.12.23.424283v2

(2) - The R346K Mutation in the Mu Variant of SARS-CoV-2 Alter the Interactions with Monoclonal Antibodies from Class 2: A Free Energy of Perturbation Study - https://www.biorxiv.org/content/10.1101/2021.10.12.463781v1

https://www.linkedin.com/feed/update/urn%3Ali%3Aactivity%3A6870177115547963392/

 

28 Nov 2021 / 6:24 CET  Filip Fratev / Micar Innovation (Micar21)

Our preliminary FEP data showed that the SARS-CoV-2 Omicron’s (B.1.1.529 lineage) Q498R, Y505H and G496S mutations drastically increase the binding to ACE2, which is an indication of its transmission.

Our preliminary FEP data showed that the SARS-CoV-2 Omicron’s (B.1.1.529 lineage) Q498R, Y505H and G496S mutations drastically increase the binding to ACE2, which is an indication of its transmission. They enhanced the binding by 98, 14 and 13 times, respectively, which transforms the S1-RBD to a picomolar binder! Our estimations are based on the structures of both Alpha and Beta variants. The K417N and T478K had a relatively small negative effect to the binding: ddG=0.44 and +0.16 kacl/mol, respectively. Initially, we are calculating the contribution of the individual mutations to the RBD-ACE2 interactions and next we will do that for their total cumulative effect. Also, we expect an improvements of the results after the multi-site FEP calculations due to the cycle closure data. Currently, we observed a difference only for G496S which has a ddG= -0.82 and -0.23 kcal/mol in Alpha and Beta variants, most likely due to the not good convergence in Beta. We will improve that during the next hours and expect the data for Q493K. The latter and Glu484Ala and Lys417Asn can be described as an individual hot spot of mutations.

https://www.linkedin.com/feed/update/urn:li:activity:6870177115547963392/

 

 29 Nov 2021 / 6:49 CET  Filip Fratev / Micar Innovation (Micar21)

We received the all FEP data for the Omicron’s RBD-ACE2 binding. It is clear now that the Q498R and Q493K are the main players in these interactions.

We received almost the all FEP data for the Omicron’s RBD-ACE2 binding. It is clear now that the Q498R and Q493K are the main players in these interactions. However, there is a competition between them leading to decrease of the total binding; i.e. similar to case of N501Y and K417N tandem of mutations in Beta variant. What is exactly this decrease we will know soon but the ddG of Q493K has a positive value. The transformation of not charged to charged residues in known to produce a significant bias in FEP calculations. This is valid indeed for both Q498R and Q493K. Thus, we developing a special protocol in order to describe these significant changes which are responsible for the RBD-ACE2 binding in Omicron. In addition, our results shown that the N440K and G446S have indeed a small effect to the RBD-ACE2 interactions and the ddG values were -0.2 and +0.21 kcal/mol; i.e. in frame of possible error. We expected the G446S in a combination with G498R and surrounding residues additionally may stabilize this constellation of harmful mutations and in particular Arg498 but this turn out to be not true (ddG=0.24).

https://www.linkedin.com/feed/update/urn:li:activity:6870982318018854912/

Language(s)
English
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