The NanoB2A group is a multidisciplinary research team led by Prof. Laura M. Lechuga. We are physicists, engineers, chemists, and biologists working in the broad field of Nanobiotechnology. Our motivation is to develop new and cutting-edge biosensor nanotechnologies using photonics, one of the key technologies of the 21st century, to promote and boost healthcare and well-being for our society. Our research focuses on the development of photonic point-of-care biosensors and their employment in clinical, biomedical, and environmental areas. We mainly exploit Nanoplasmonics and Silicon Nanophotonics technologies to accomplish integrated biosensing systems for the label-free, real-time, and multiplexed analysis at the point of care.
Specialisation and expertise
Our activity encompasses the entire process of generating new photonic biosensor devices, including fundamental research and theoretical design, nanofabrication, surface biofunctionalization, lab-on-a-chip integration, and their final validation in real scenarios. We have widely demonstrated our expertise in:
- Surface Plasmon Resonance (SPR and LSPR) biosensors: design and development of portable devices with user-friendly operation and high performance.
- Bimodal Waveguide (BiMW) biosensors: our pioneering design of interferometric nanophotonic system for ultrasensitive label-free analysis.
- Sensor biofunctionalization: unique know-how on gold and silicon surface chemistry strategies for controlled and optimum bioreceptor immobilization, including proteins, antibodies, and oligonucleotides.
- Biomedical applications: assay development and clinical validation for diagnostics and therapy monitoring of different diseases and disorders, including cancer, infections, celiac disease, allergies, etc. Our biosensors have been successfully applied for detection of proteins, antibodies, microRNA, pathogens (virus and bacteria), peptides, drugs, and also epigenetic biomarkers (alternative splicing, DNA methylation, etc.).
- Environmental applications: assay development and validation for detection and monitoring of pollutants and contaminants in water, food, etc.